Tadayasu becomes disgusted when he sees a man covered in microbes. Professor Itsuki asks everyone to buy liquor at Hiyoshi Liquor Store near the school. Tadayasu discovers the owner is the microbe monster who brews delicious sake.
Enter Tadayasu, a freshman college student who can see and talk to cute, chibi bacteria and other microscopic organisms. It's not all fun and games like it sounds, though, because it gets him into all sorts of trouble. Join Tadayasu as he enters his first year at the Agriculture University, what crazy events await him?